In science, progress is measured in small steps along the way to major discoveries. By consistently funding the most innovative research, the AKC Canine Health Foundation is realizing both small milestones and major breakthroughs in canine health. Your support helps us progress towards our goal to prevent, treat and cure canine disease.
The Big (and Small) Six February 12, 2014
Recently researchers determined that approximately half of the weight differences seen across dog breeds can be explained by variations in and around only six genes. Studies such as this one can provide insight into some of the size differences seen in humans as well as growth-related health concerns in dogs and humans.
Investigating Influenza February 10, 2014
In the middle of winter, it sometimes seems like everyone is down with the flu. However, humans aren’t the only species that can suffer from influenza. Dogs can get it too, and a few years back a novel strain of influenza began showing up in the canine population. With the support of the AKC Canine Health Foundation researchers set out to track the virus across the United States.
Using Technology to Track Disease January 13, 2014
Leptospirosis, which is caused by a waterborne parasite, can infect both dogs and humans. Without effective treatment, it can cause serious kidney and liver damage. It can even lead to death. Researchers from the University of California-Davis have been investigating the spread of leptospirosis using specialized mapping programs.
New Treatment Goes After Notoriously Tough Cancer Stem Cells November 25, 2013
Canine hemangiosarcoma is relatively common in companion animals. It is also relatively difficult to treat, as they quickly become resistant to conventional forms of therapy. Scientists from the University of Minnesota wondered if targeted toxins might be an effective way of addressing cancers. The results were quite promising.
Once the a genetic test was available for EIC, it quickly became clear that the existence of the DNM1 mutation didn’t explain all cases of EIC. Some Labrador Retrievers with EIC didn’t have both copies of the mutation, others didn’t have copies at all. Therefore, the scientists from the University of Minnesota and the University of Saskatchewan who had developed the test set out to determine if they could understand whether the EIC seen in dogs without the mutation was really the same condition.
The Health Implications of Early Spay and Neuter May 6, 2013
Recently scientists from the University of California-Davis used a large veterinary database to determine what exactly the implications of neutering might be for a breed of dogs that is one of the most popular in the U.S. – the Golden Retriever. The results were fascinating: timing of spay and neuter did affect the risk of a dog developing serious health problems.
Dark Colored Dogs Highlight Cancer's Complexity April 17, 2013
Standard poodles are at risk of an aggressive type of cancer known as squamous cell carcinoma of the digit (SCDD). However, not all poodles are equally susceptible to SCDD. Dark colored poodles are at high risk of this cancer, while light colored dogs are almost never affected. Researchers recently found the genetic mutations that are likely responsible for the difference.
New System Developed for Studying B-cell Cancers February 15, 2013
With the help of the AKC Canine Health Foundation, Dr. Daisuke Ito and colleagues set out to find an alternative to traditional cell culture techniques for studying DLBCLs. Instead of creating a DLBCL-like cell artificially, using viral infection, they wanted to find a way to grow and maintain the diverse collection of B-cells found in an actual canine cancer.
Selecting First-Choice Anti-Seizure Medications for Dogs February 15, 2013
Epilepsy is a medical condition found in both dogs and humans. The seizures it causes can be quite dangerous, and although it is often treatable, there has been some debate over which anti-epileptic drug (AED) is most effective.
The Role of Oxidative Stress in IMHA January 15, 2013
Immune-mediated hemolytic anemia (IMHA) is a major cause of severe anemia in American dogs. IMHA occurs when the immune system attacks and destroys oxygen-carrying red blood cells (RBC), leading to symptoms including exhaustion, weakness, and panting. However, although scientists have known for years that the immune system destroys the RBCs in dogs with IMHA, they still have no idea what prompts it to attack.
Help Future Generations of Dogs
Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.