Hemangiosarcoma Initiative

About the Hemangiosarcoma Research Initiative


Hemangiosarcoma is an aggressive and common cancer in dogs.  It can develop in any tissue or organ, but the most commonly affects the spleen, right atrium of the heart, and the skin.

Since 1995, CHF and its donors have invested over $3.8 million in 27 grants in understanding mechanisms and causes, new targets for treatment, and early diagnostics for canine hemangiosarcoma, an aggressive cancer in dogs. CHF, along with its donors, continues to address this devastating disease through this initiative launched in 2018.

$3.8M invested in hemangiosarcoma research since 1995.

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Learn More about the Initiative

Learn more about the Hemangiosarcoma Research Initiative by watching the January 9, 2019 AKC.TV Ask the Expert interview with AKC Canine Health Foundation former CEO, Dr. Diane Brown.

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Why Study It?

  • While cutaneous masses (affecting the skin) are often treatable by tumor excision, tumors affecting internal organs are associated with poorer prognosis and are almost always incurable.
  • Hemangiosarcoma is often called the “silent killer” because the tumors are often not detected until the later stages of the disease, and even dogs harboring large tumors may show no clinical signs or evidence that they have a life threatening disease.
  • Existing treatments have not improved the overall survival times for dogs with this disease.



Our Progress So Far


Current CHF-Funded Studies

The AKC Canine Health Foundation (CHF) believes in the advancement of science to meet the unmet medical needs of the dogs that are such an important part of our daily lives. Here we list the important active studies in this research program area.

 02806-MOU Strategic Prevention of Canine Hemangiosarcoma: Lifetime Follow-Up
 02759 Reprogramming the Tumor Immune Niche in Canine Hemangiosarcoma
 02746-A Evaluation of Serum miRNA as a Diagnostic Tool for Canine Splenic Hemangiosarcoma
 02534 Clinical Trial for Evaluation of Propranolol and Doxorubicin in the Treatment of Canine Hemangiosarcoma
 02519 Prevalence of Bartonella spp. Infection in Dogs with Cardiac and Splenic Hemangiosarcomas within and between Geographic Locations
 02510-T Identification of Novel Synthetic Lethal Partners to Optimize PI3K Targeted Therapies in Canine Hemangiosarcoma



 02234-MOU  A Novel Approach for Prevention of Canine Hemangiosarcoma
 02217  A Novel Mechanism to Regulate the Growth of Canine Hemangiosarcoma

Webinars

See what Douglas H. Thamm, VMD, DACVIM (Oncology) has to say about cancer prevention as well as what we know about the connection between the use of vaccines, flea, tick and heartworm preventatives and cancer risk in dogs here.

 
VetVine

Douglas H. Thamm, VMD, DACVIM (Oncology) updates us on his hemangiosarcoma research, presenting on the clinical presentation, staging, therapy and prognosis in canine hemangiosarcoma. He also talks about his recent findings about the biology of the disease, and early diagnosis and new treatment strategies here.

Articles

Publications

Researchers awarded grants through CHF continue to produce a wealth of publications contributing to scientific knowledge. These scientific articles, grouped by publication date, are a result of CHF-funded hemangiosarcoma research!


  • Borgatti, A., Fieberg, A., Winter, A. L., Stuebner, K., Taras, E., Todhunter, D., Masyr, A., Rendhal, A., Vallera, D. A., Koopmeiners, J. S., & Modiano, J. F. (2020). Impact of Repeated Cycles of EGF Bispecific Angiotoxin (eBAT) Administered at a Reduced Interval from Doxorubicin Chemotherapy in Dogs with Splenic Hemangiosarcoma. Veterinary and Comparative Oncology. https://doi.org/10.1111/vco.12590
  • Lashnits, E., Neupane, P., Bradley, J. M., Richardson, T., Thomas, R., Linder, K. E., Breen, M., Maggi, R. G., & Breitschwerdt, E. B. (2020). Molecular prevalence of Bartonella, Babesia, and hemotropic Mycoplasma species in dogs with hemangiosarcoma from across the United States. PLOS ONE, 15(1), e0227234. https://doi.org/10.1371/journal.pone.0227234
  • Megquier, K., Turner-Maier, J., Swofford, R., Kim, J.-H., Sarver, A. L., Wang, C., Sakthikumar, S., Johnson, J., Koltookian, M., Lewellen, M., Scott, M. C., Schulte, A. J., Borst, L., Tonomura, N., Alfoldi, J., Painter, C., Thomas, R., Karlsson, E. K., Breen, M., … Lindblad-Toh, K. (2019). Comparative Genomics Reveals Shared Mutational Landscape in Canine Hemangiosarcoma and Human Angiosarcoma. Molecular Cancer Research, 17(12), 2410–2421. https://doi.org/10.1158/1541-7786.MCR-19-0221
  • Kennedy, K., Thomas, R., Durrant, J., Jiang, T., Motsinger-Reif, A., & Breen, M. (2019). Genome-wide DNA copy number analysis and targeted transcriptional analysis of canine histiocytic malignancies identifies diagnostic signatures and highlights disruption of spindle assembly complex. Chromosome Research. https://doi.org/10.1007/s10577-019-09606-0
  • Kim, J.-H., Frantz, A. M., Sarver, A. L., Gorden Klukas, B. H., Lewellen, M., O’Brien, T. D., Dickerson, E. B., & Modiano, J. F. (2018). Modulation of fatty acid metabolism and immune suppression are features of in vitro tumour sphere formation in ontogenetically distinct dog cancers. Veterinary and Comparative Oncology, 16(1), E176–E184. https://doi.org/10.1111/vco.12368
  • Borgatti, A., Koopmeiners, J. S., Sarver, A. L., Winter, A. L., Stuebner, K., Todhunter, D., Rizzardi, A. E., Henriksen, J. C., Schmechel, S., Forster, C. L., Kim, J.-H., Froelich, J., Walz, J., Henson, M. S., Breen, M., Lindblad-Toh, K., Oh, F., Pilbeam, K., Modiano, J. F., & Vallera, D. A. (2017). Safe and Effective Sarcoma Therapy through Bispecific Targeting of EGFR and uPAR. Molecular Cancer Therapeutics, 16(5), 956–965. https://doi.org/10.1158/1535-7163.MCT-16-0637
  • Dickerson, E., & Bryan, B. (2015). Beta Adrenergic Signaling: A Targetable Regulator of Angiosarcoma and Hemangiosarcoma. Veterinary Sciences, 2(3), 270–292. https://doi.org/10.3390/vetsci2030270
  • Regan, D. P., Escaffi, A., Coy, J., Kurihara, J., & Dow, S. W. (2017). Role of monocyte recruitment in hemangiosarcoma metastasis in dogs: CCL2-recruited monocytes in canine hemangiosarcoma. Veterinary and Comparative Oncology, 15(4), 1309–1322. https://doi.org/10.1111/vco.12272
  • Grimes, J. A., Prasad, N., Levy, S., Cattley, R., Lindley, S., Boothe, H. W., Henderson, R. A., & Smith, B. F. (2016). A comparison of microRNA expression profiles from splenic hemangiosarcoma, splenic nodular hyperplasia, and normal spleens of dogs. BMC Veterinary Research, 12(1). https://doi.org/10.1186/s12917-016-0903-5
  • Andersen, Nicholas J., Boguslawski, E. B., Kuk, C. Y., Chambers, C. M., & Duesbery, N. S. (2015). Combined inhibition of MEK and mTOR has a synergic effect on angiosarcoma tumorgrafts. International Journal of Oncology, 47(1), 71–80. https://doi.org/10.3892/ijo.2015.2989
  • Im, K. S., Graef, A. J., Breen, M., Lindblad-Toh, K., Modiano, J. F., & Kim, J.-H. (2015). Interactions between CXCR4 and CXCL12 promote cell migration and invasion of canine hemangiosarcoma: CXCR4/CXCL12 in HSA migration and invasion. Veterinary and Comparative Oncology, 15(2), 315–327. https://doi.org/10.1111/vco.12165Kim, Jong-Hyuk, Graef, A., Dickerson, E., & Modiano, J. (2015). Pathobiology of Hemangiosarcoma in Dogs: Research Advances and Future Perspectives. Veterinary Sciences, 2(4), 388–405. https://doi.org/10.3390/vetsci2040388
  • Rodriguez, A. M., Graef, A. J., LeVine, D. N., Cohen, I. R., Modiano, J. F., & Kim, J.-H. (2015). Association of Sphingosine-1-phosphate (S1P)/S1P Receptor-1 Pathway with Cell Proliferation and Survival in Canine Hemangiosarcoma. Journal of Veterinary Internal Medicine, 29(4), 1088–1097. https://doi.org/10.1111/jvim.13570

  • Borgatti, A. (2014). Binding of VEGF-A to canine cancer cells with preferential expression of VEGFR1. Veterinary World, 7(1), 1–6. https://doi.org/10.14202/vetworld.2014.1-6
  • Gorden, B. H., Kim, J.-H., Sarver, A. L., Frantz, A. M., Breen, M., Lindblad-Toh, K., O’Brien, T. D., Sharkey, L. C., Modiano, J. F., & Dickerson, E. B. (2014). Identification of Three Molecular and Functional Subtypes in Canine Hemangiosarcoma through Gene Expression Profiling and Progenitor Cell Characterization. The American Journal of Pathology, 184(4), 985–995. https://doi.org/10.1016/j.ajpath.2013.12.025
  • Kim, Jong-Hyuk, Frantz, A. M., Anderson, K. L., Graef, A. J., Scott, M. C., Robinson, S., Sharkey, L. C., O׳Brien, T. D., Dickerson, E. B., & Modiano, J. F. (2014). Interleukin-8 promotes canine hemangiosarcoma growth by regulating the tumor microenvironment. Experimental Cell Research, 323(1), 155–164. https://doi.org/10.1016/j.yexcr.2014.02.020
  • Koopmeiners, J. S., & Modiano, J. (2014). A Bayesian adaptive Phase I-II clinical trial for evaluating efficacy and toxicity with delayed outcomes. Clinical Trials (London, England), 11(1), 38–48. https://doi.org/10.1177/1740774513500589
  • Thomas, R., Borst, L., Rotroff, D., Motsinger-Reif, A., Lindblad-Toh, K., Modiano, J. F., & Breen, M. (2014). Genomic profiling reveals extensive heterogeneity in somatic DNA copy number aberrations of canine hemangiosarcoma. Chromosome Research, 22(3), 305–319. https://doi.org/10.1007/s10577-014-9406-z
  • Andersen, N. J., Nickoloff, B. J., Dykema, K. J., Boguslawski, E. A., Krivochenitser, R. I., Froman, R. E., Dawes, M. J., Baker, L. H., Thomas, D. G., Kamstock, D. A., Kitchell, B. E., Furge, K. A., & Duesbery, N. S. (2013). Pharmacologic Inhibition of MEK Signaling Prevents Growth of Canine Hemangiosarcoma. Molecular Cancer Therapeutics, 12(9), 1701–1714. https://doi.org/10.1158/1535-7163.MCT-12-0893
  • Kim, J. H., Anderson, K. L., Frantz, A. M., Graef, A. J., Scott, M. C., Sharkey, L. C., ... & Modiano, J. F. (2013). Constitutive expression and roles of interleukin-8 in canine hemangiosarcoma. In BMC proceedings (Vol. 7, No. S2, p. P35). BioMed Central. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3624508/
  • Schappa, J. T., Frantz, A. M., Gorden, B. H., Dickerson, E. B., Vallera, D. A., & Modiano, J. F. (2013). Hemangiosarcoma and its cancer stem cell subpopulation are effectively killed by a toxin targeted through epidermal growth factor and urokinase receptors: Bispecific ligand-targeted toxins. International Journal of Cancer, 133(8), 1936–1944. https://doi.org/10.1002/ijc.28187
  • Koopmeiners, J. S., & Modiano, J. F. (2012). Extending the TITE CRM to Multiple Outcomes with Application to a Phase 1 Clinical Trial in Canine Hemangiosarcoma.University of Minnesota. Thesis. https://api.semanticscholar.org/CorpusID:18648350
  • Tamburini, B. A., Phang, T. L., Fosmire, S. P., Scott, M. C., Trapp, S. C., Duckett, M. M., Robinson, S. R., Slansky, J. E., Sharkey, L. C., Cutter, G. R., Wojcieszyn, J. W., Bellgrau, D., Gemmill, R. M., Hunter, L. E., & Modiano, J. F. (2010). Gene expression profiling identifies inflammation and angiogenesis as distinguishing features of canine hemangiosarcoma. BMC Cancer, 10(1). https://doi.org/10.1186/1471-2407-10-619
  • Tamburini, B. A., Trapp, S., Phang, T. L., Schappa, J. T., Hunter, L. E., & Modiano, J. F. (2009). Gene Expression Profiles of Sporadic Canine Hemangiosarcoma Are Uniquely Associated with Breed. PLoS ONE, 4(5), e5549. https://doi.org/10.1371/journal.pone.0005549Dickerson, E. B., Thomas, R., Fosmire, S. P., Lamerato-Kozicki, A. R., Bianco, S. R., Wojcieszyn, J. W., Breen, M., Helfand, S. C., & Modiano, J. F. (2005). Mutations of Phosphatase and Tensin Homolog Deleted from Chromosome 10 in Canine Hemangiosarcoma. Veterinary Pathology, 42(5), 618–632. https://doi.org/10.1354/vp.42-5-618

  • Akhtar, N., Padilla, M. L., Dickerson, E. B., Steinberg, H., Breent, M., Auerbach, R., & Helfand, S. C. (2004). Interleukin-12 Inhibits Tumor Growth in a Novel Angiogenesis Canine Hemangiosarcoma Xenograft Model. Neoplasia, 6(2), 106–116. https://doi.org/10.1593/neo.03334
  • Fosmire, S. P., Dickerson, E. B., Scott, A. M., Bianco, S. R., Pettengill, M. J., Meylemans, H., Padilla, M., Frazer-Abel, A. A., Akhtar, N., Getzy, D. M., Wojcieszyn, J., Breen, M., Helfand, S. C., & Modiano, J. F. (2004). Canine malignant hemangiosarcoma as a model of primitive angiogenic endothelium. Laboratory Investigation, 84(5), 562–572. https://doi.org/10.1038/labinvest.3700080



How to Get Involved


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Donate to Support Hemangiosarcoma Research

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Participate in Research

Learn how you and your dog can help canine health researchers!

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Sponsor the Hemangiosarcoma Research Initiative

Sponsor today at a $2,500+ level!

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Thank you to the Sponsors of the Hemangiosarcoma Research Initiative!

Champion Sponsors ($50,000+)

 
Golden Retriever Foundation Logo1
 
ABCF Logo1
 
American German Shepherd Dog Charitable Foundation logo
 
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Sponsors ($2,500+)

Alaskan Malamute Club of America, Inc.
Alice's Fund/Michael Heltzer
American Belgian Tervuren Club, Inc.
American Bloodhound Club
American Bullmastiff Association
American Pointer Club
Australian Shepherd Health & Genetics Institute, Inc.
Australian Terrier Trust
Basset Hound Club of America, Inc.
Bedlington Terrier Club of America
Bernese Mountain Dog Club of America
Bouvier Health Foundation
Briard Club of America Health & Education Trust
Chesapeake Kennel Club of Maryland, Inc.
Chinese Shar-Pei Charitable Trust
Chinese Shar-Pei Club of America, Inc.
Clumber Spaniel Health Foundation
Dachshund Club of America, Inc.
Flat-Coated Retriever Foundation
French Bulldog Club of America
Golden Retriever Club of San Diego County
German Shorthaired Pointer Club of America, Inc.
German Wirehaired Pointer Club of America
Gordon Setter Club of America, Inc.
Great Pyrenees Club of America
Health & Rescue Foundation of the Petit Basset Griffon Vendeen Club of America
Irish Setter Club of America Foundation, Inc.
Irish Setter Club of Milwaukee
Irish Wolfhound Club of America, Inc.
Keeshond Club of America
Labrador Retriever Club, Inc.
Leonberger Health Foundation
Master National Retriever Club Foundation
Miranda Fund
National Beagle Club
Nespola Charitable Foundation
Newfoundland Club of America Charitable Trust
Otterhound Club of America
Poodle Club of America Foundation
Rottweiler Health Foundation
Saluki Health Research, Inc.
Scottish Terrier Club of America Health Trust Fund
SCWTCA Endowment, Inc.
Versatility in Poodles, Inc.
Vizsla Club of America Welfare Foundation
Weimaraner Foundation Fund Corporation

Sponsor Hemangiosarcoma Research

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